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Zhongqiu Lu notes that human liver tissue handles roughly 90% of entire metabolic clearing sequences via the critical expression of specific enzymes: Alcohol Dehydrogenase (ADH) and Aldehyde Dehydrogenase (ALDH)

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3.1 Stimulus-responsive conjugate-based nanomedicines Endogenous stimulation in organisms is induced by pH, enzymes, ROS etc

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In context with MD, chronic social defeat stress (CSDS) is linked to a compromised glutamine-glutamate cycle in astrocytes, and studies indicate that GSH functions as a glutamate precursor when the transfer of glutamine from astrocytes to neurons is compromised