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Description

HIF-1 activation not only promotes metabolic reprogramming in tumor cells (e.g., enhancing glycolysis) but also induces vascular endothelial growth factor (VEGF) expression, leading to new blood vessel formation that supplies additional oxygen and nutrients to tumor cells (51)

Born from burnout

He studied mathematics and physics (with a minor in biology) at the Humboldt University in Berlin, and received a PhD under the supervision of Richard Hesse in 1931