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SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

In vivo, ANKIB1 deficiency limits TLR3-induced IFN induction and, consequently, reduces lethality in a TLR3-driven interferonopathy model, whereas it increases vulnerability of mice to herpes simplex virus-1 (HSV-1) infection, known to depend on cGASSTING-mediated IFN induction for survival, providing compelling evidence that ANKIB1-mediated K11 ubiquitination is crucial for innate immune signalling in vivo

doi:10.1016/S0014-2999(97)00044-7

Another report found a case of scurvy following KD use in a 5-year-old girl on the autism spectrum ( Biotin (vitamin B7) supports keratin production and is important for skin, hair, and nail health (248)