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Description

For the comparison of multiple datasets of normal distribution, one-way ANOVA with Holmdks test for multiple comparisons correction was used as in Fig 6D

This has given rise to the concept of a therapeutic window, which is a range of doses or blood/plasma concentrations within which most individuals should show a beneficial response with minimal risk of adverse effects (illustrated by response 1 in Fig

Boukovala M, Spetsieris N, Weldon JA, Tsikkinis A, Hoang A, Aparicio A, Tu SM, Araujo JC, Zurita AJ, Corn PG, Pagliaro L, Kim J, Wang J, Subudhi SK, Tannir NM , Logothetis CJ, Troncoso P, Wen S, Efstathiou E