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JAK inhibitors represent another class of targeted therapy, but like anti-TNF agents, they come with significant immunosuppressive effects

Meanwhile, hippocampal microRNA-26a-3p deletion is participating in the amelioration of neuroinflammation and behavioral deficits in rats through the p38 MAPK signaling pathway ( Listening to music has been shown to upregulate microRNA-132, increase hippocampal neuronal plasticity, promote CNS myelin formation, and further regulate striatal dopamine levels (Nair et al., 2021)

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It causes double-strand breaks (DSB), which can be fixed by either the homologous directed repair pathway (HDR) or error-prone non-homologous end junction (NHEJ) pathway, which are both endogenous self-healing processes [48]