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While this form of treatment is generally well-tolerated and can significantly improve quality of life, it's not uncommon to experience a few mild side effects afterward

AOD-9604 does not affect IGF-1 because it lacks the receptor-binding domains necessary to activate growth hormone receptors

The loss of insulin sensitivity of hippocampal CA1 pyramidal neurons can subsequently cause long-term Ca 2+ -dependent afterhyperpolarizations (AHPs), which can produce significant cognitive and memory impairment in the short term and throughout life, contributing to depression (122, 123)

Understanding how altered BDNF-TrkB signaling, particularly in iSPNs, might lead to early dopamine dysfunction in Huntington's disease could provide targets for potential preventative therapy