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This significant rise in prevalence over the past three decades has raised concerns, and there is evidence suggesting that environmental factors contribute to the development of AD [5]

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doi: 10.2169/internalmedicine.52.8333 115 Viveros-ParedesJ

All study groups modify the intensity of postinduction therapy on the basis of a variety of prognostic factors, including NCI risk group, immunophenotype, early response determinations, and cytogenetics and genomic alterations.[4] Detection of the BCR :: ABL1 fusion (i.e., BCR :: ABL1 -positive ALL) leads to immediate changes in induction therapy, including the addition of a tyrosine kinase inhibitor, such as imatinib or dasatinib.[5] Risk-based treatment assignment requires the availability of prognostic factors that reliably predict outcome