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The clinical symptoms of acute bovine babesiosis are fever, limb weakness, anemia, and sometimes animal death (138)

Gut microbes are the true first line of defense against toxins The Gut as a Detoxification Organ You may recall learning that there are three primary phases of detoxification: Phase I: cytochrome P450 and other enzymes introduce polar groups via oxidation, reduction, or hydrolysis Phase II: conjugation via processes like methylation, acetylation, or sulfonation Phase III: further modification and excretion The Gut as Phase 0.5 Detoxification Phase I cytochrome P450 is often referred to as the first line of defense against environmental toxins

And a recent research shown that DNA polymerase gamma deficiency induced mtROS increasing which promotes RICTOR expression to trigger pro-survival autophagy [74]

Mol Biol Rep 50:65056516 Srivastava R, Choudhury PK, Dev SK, Rathore V (2021) Neuroprotective effect of -pinene self-emulsifying nanoformulation against 6-OHDA induced neurotoxicity on human SH-SY5Y cells and its in vivo validation for anti-Parkinsons effect