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fumigatus also has specific enzymes for detoxification of ROS produced by macrophages and neutrophils, such as five catalases (catA, cat1/catB, catC, catE, and cat2)48,208,215 and four superoxide dismutases (SODs): a cytoplasmic Cu/ZnSOD (Sod1), a mitochondrial MnSOD (Sod2), a cytoplasmic MnSOD (Sod3), and Sod4 displaying a MnSOD C-terminal domain.87,113,147 Deletion of catA, a conidial catalase, resulted in increased susceptibility of conidia to H2O2in vitro, but the virulence of the mutant strain did not change in a murine model.215

10.1016/j.ejphar.2022.175213 2 AhmadN.AhmadR.AlrasheedR

Collectively, both internal and external datasets consistently indicate that tumor cells have relatively elevated VB2 metabolism