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In addition, the UC SUCCESS trial showed significantly higher rates of corticosteroid-free remission (39.7 vs

doi: 10.1016/j.jad.2017.12.049 34 Samare-NajafMNeisyASamarehAMoghadamDJamaliNZareiRet al

Additionally, no signaling pathway analysis was conducted, which limits mechanistic insights into the observed pharmacological effects of marmelosin

A study in healthy non-human primates that received a high-protein meal followed by an oral dose of 370 mg/kg CDX-6512 treatment led to a statistically significant, dose-dependent reduction in plasma methionine levels, demonstrating the effectiveness of the enzyme in breaking down dietary methionine in a physiologically-similar model to humans (46)