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Before the surge of genetic evidence supporting the association of NMDAR malfunction with schizophrenia, hypofunction of NMDARs in the pathogenesis of schizophrenia was originally identified from observations on the psychotomimetic effects of non-competitive NMDAR antagonists

doi: 10.1016/S0014-5793(98)01686-X 41 IvesANomuraJMartinonFRogerTLeRoyDMinerJNet al

Regulatory bodies like the FDA, EMA, and MHRA demand precise reporting protocols to maintain global standards