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Discard any opened vial after 28 days to ensure antimicrobial integrity

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The larger vial size reflects typical dosing in preclinical protocols in which TB-500 is administered systemically and requires higher absolute amounts.

The highest resolution achieved in cryo-EM for protein structure determination is currently 1.25 (as reported for apoferritin, which is composed of 24 subunits arranged in a symmetrical structure, with a total molecular mass of 440480 kDa) (Yip et al., 2020)

Predrag Sikiric, [email protected] This article was submitted to Translational Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers