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Description

S13A) and lipid peroxidation (Fig

Trace elements in human nutrition (II) - an update

Immunity 23 , 419429 (2005)

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Thus, the PPPgenerated NADPH rescues xCT-overexpressing cancer cells (xCT high cancer cells) from ferroptosis, demonstrating that xCT high cancer cells become highly dependent on the glucose-PPP pathway (i.e., NADPH addiction) to inhibit ferroptosis [Figure 1A]