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For contaminants with a poor toxicological database, e.g

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The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium

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Animals were exposed to a gas mixture of 5% O 2 and 95% N 2 (mixed by volume) for 20 min to induce global hypoxia