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Combined therapy with DR5-targeting antibody-drug conjugate and CDK inhibitors as a strategy for advanced colorectal cancer

Oxidative depletion of BH 4 as a cause of eNOS uncoupling and endothelial dysfunction has been described in vivo, in the aortas of mice with deoxycorticosterone acetate-salt (DOCA-salt) hypertension [29], spontaneously hypertensive mice and rats [97, 98], apolipoprotein E (poE)-deficient mice [99], or aged mice and rats [33, 100]

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PMID: 35081333 Redox Biol2022 Aug;54:102383

Another study showed that food-derived compound apigenin, a modulator of PPAR, can increase Nrf2 nucleus translocation to inhibit the expression of lipid metabolism-related genes and increase the expression of oxidative stress-related genes, resulting in amelioration of HFD-induced NAFLD [211]