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erinaceus extract from mycelia has also been demonstrated to inhibit TNF--induced angiogenesis and generation of reactive oxygen species through the suppression of matrix metalloproteinase-9- and nuclear factor-B signalling pathways (46)

Importantly, post-target CDDP resistance is rarely (if ever) specific, rather extending to other DNA-damaging agents (including radiation), 27, 33, 159 as well as to cytotoxic stimuli that engage a wide panel of primary targets (e.g., death receptor agonists)

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