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Being about 25% in 2010, it has risen to 29.6% in 2016 and is projected to rise further, in particular up to 2050, and eventually reach 51.2% in 2070 (Economic and Financial Affairs 2017)

During its maturation, granulosa cells which line the follicle release estrogen (also known scientifically as estradiol) which stimulates growth and thickening of the uterine lining