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Many people report feeling more energized and alert within a few hours or days after receiving a B12 injection

doi: 10.1093/nsr/nwae100 27 HanJ

This microbiota-reshaping effect was associated with restored intestinal permeability, increased short-chain fatty acid (SCFA) production, and reduced levels of pro-inflammatory cytokines

Kronfol MM, Jahr FM, Dozmorov MG, Phansalkar PS, Xie LY, Aberg KA, McRae M, Price ET, Slattum PW, Gerk PM, McClay JL (2020) DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver