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[DOI] [PMC free article] [PubMed] [Google Scholar] 201.Li LF, Hao RN, Qin JJ, Song J, Chen XF, Rao F, et al

The distinct configuration of the GAMEN motif in IRAP generates additional space around residues 3 and 4 of the bound linear peptide, which could be used for the accommodation of bulkier side chains, possibly affording a broader selectivity for peptides

On the regulatory side, this ingredient is well-studied and broadly considered safe as used

Independent groups have observed consistent patterns across the published research record, providing cross-laboratory replication for the core mechanism findings documented in the foundational papers cited above

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