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L-Glutathione is a naturally occurring antioxidant made from three amino acids cysteine, glutamine, and glycine

Ukrainian non-state decoration bestowed by the VGO "Kraina" (NGO) at the request of Mr Anatoliy Ostapenko (member of the Verkhovna Rada) [348] Honorary doctorate from Stockton University (United States, 2023)

These modifications result from direct ROS attack on amino acids (proline, arginine, lysine, threonine) or indirectly via reactive aldehydes from lipid peroxidation (MDA, 4-hydroxynonenal), or through reactions with reducing sugars and advanced glycation end-products (Pinzaru et al., 2023)

Specifically, the PTEN-induced kinase 1 (PINK1)/Parkin pathway is a classic mechanism that activates mitophagy by mediating the recognition of damaged mitochondria

These therapies are backed by clinical guidelines and decades of use