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One possible criticism of this study or that while what we are observing with yeast may not be true, in case of mammalian cells response could be different and one might be experiencing oxidative stress response in the mammalian system, though not the yeast model

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96 Of note, GTPSCS functions as a lactyl-CoA synthetase in the nucleus and interacts with p300 to form a histone lactyltransferase complex to synergistically modulate H3K18la in this process

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Horizontal carryover of proteins on one-dimensional polyacrylamide gels may jeopardize gel-enhanced liquid chromatography-mass spectrometry proteomic interpretations