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Description

Immunity 57 , 528540.e526 (2024)

Additionally, prolonged exposure to acrylamide has been linked to disruptions in brain lipid metabolism and neuroinflammation, notably impacting myelin and phospholipid metabolism (325)

This is because predictive models must be developed based on the DILI mechanism, be sufficiently adaptable to various situations, and predict risks early in the drug development process

Although the overall structures of these two N-TXNIP proteins and the N-TXNIP protein used here are very similar, significant conformational changes were detected in the 5 and Cys63-containing 6 strands (Fig