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This suggests that in the absence of opsonizing antifungal antibodies, the nature of the interaction between the innate immune cells and with fungi may be modified with subsequent development of long-lasting antifungal immunity [74]

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Apc-mutated intestinal tumors lacking Stard7 are sensitive to mTORC1 inhibition Given the fact that intestinal tumors arising from constitutive Wnt signaling and lacking Stard7 show enhanced mTORC1 signaling, we hypothesized that these malignancies would be very sensitive to mTORC1 pharmacological inhibition

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DSouza RF, Woodhead JS, Hedges CP, Zeng N, Wan J, Kumagai H, et al