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Jabbour EJ, Short NJ, Huang X, Maiti A, Kadia TM, Daver N, Borthakur G , DiNardo CD, Pemmaraju N, Sasaki K, Estrov Z, Verstovsek S, Ravandi F, Alvarado Y, Sekeres MA, Komrokji RS, Steensma DP, DeZern AE, Roboz GJ, Miller D, Dong X, Kantarjian HM, Garcia-Manero G

As damage from smoking or even pollution accumulates to the respiratory tract and the lungs, oxygen and carbon dioxide (CO2) exchange suffers, making it difficult to breathe

Genes with a Bonferroni-corrected P value of less than 0.05 were considered to be differentially expressed

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The clinical utility of conventional copper chelators is limited by dose-dependent toxicities, primarily stemming from systemic copper deficiency and off-target chelation of essential metals, such as zinc and iron