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Besides, arsenite selectively activated p38 and JNK3 in cerebellar neurons (Namgung and Xia, 2001)

Contrarily, low-level local ROS are crucial for regulating essential transcription factors such as NF-B/I-B, Nrf2/KEAP1, AP-1, p53, HIF-1, and PTK/PTP, as well as for maintaining cellular homeostasis (MAPK/ERK, PTK/PTP, PI3K-AKT-mTOR)