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Restoring circadian rhythms can also enhance the quality of sleep and overall cognitive function, which are frequently disrupted in older populations

Receptor-mediated targeting: mannose receptor-targeted nanocarriers (e.g., liposomes and polymeric nanoparticles) decorated with URAT1-specific ligands demonstrate enhanced tubular accumulation, minimizing gastrointestinal adverse effects associated with systemic drug exposure ( 3.6.2 Spatiotemporally controlled sustained-release platforms Microsphere/liposome systems: PLGA- or lipid-encapsulated uricase formulations achieve weeks-to-months sustained release, reducing injection frequency and improving adherence in chronic regimens ( 2 composites) trigger drug release in acidic microenvironments (e.g., inflammation sites and crystal deposits), enhancing local efficacy (Mohamadi Bian and Moghadam, 2025

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