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Description

Icariin II (ICS II), a flavonoid from Epimedium koreanum , triggers ferroptosis in renal carcinoma by downregulating GPX4 in a p53-independent manner and upregulating miR-324-3p, which suppresses GPX4 expression, leading to iron accumulation, lipid peroxidation, and GSH depletion (234)

There is also in vivo evidence, with trimetazidine (5 mg/kg) pre-treatment attenuating superoxide levels in the rat heart following ischemia/reperfusion [171]