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Regarding the point, it is well-established that one of the most common complications seen in IBD patients is iron deficiency anemia (IDA) [601]

When astrocytes take up glutamate, not only is there post-synaptic attenuation of nearby neurons, but within the astrocyte there is a switch from oxidative metabolism to aerobic glycolysis, and glucose is diverted from the TCA cycle to glycolysis and greater lactate production

Lysophosphatidic acid (LPA) is the simplest phospholipid found in nature, not only it can adjust skin function, hair follicle development, wound healing, and skin itching, but also it can play an important role in scleroderma and skin cancer (94)

Protein deficiency is rampant among the industrial workers in India and other third world countries 3 and this may be associated with adverse functional disorders of body metabolism, which is likely to be exaggerated in conditions of heavy metal toxicity

Copenhagen, Denmark: European Environment Agency