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Description

PMC 524068

In AD, A accumulation within neurons increases mitochondrial ROS production and sensitizes mitochondria to apoptosis by promoting BAX activation [80]

Their study revealed significant downregulation of key genes associated with inflammation, including the IL-6, matrix metalloproteinase-15 (MMP-15), caspase-6 and TNF- ligand

Promoter hypermethylation of tumor-suppressor genes and global hypomethylation of non-coding regions contribute to chromosomal instability and tumorigenesis (Ting et al., 2006)