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The importance of maintaining the metabolic health of the carnitine pool is emphasized by the high demand for carnitine in tissues that cannot synthesize carnitine, such as the myocardium and skeletal muscle

Control group: mice are given distilled water through 15 days and physiological saline instead of Methotrexate is administered on the 8th day in a similar manner

This process can be initiated by iron-catalyzed Fenton chemistry, in which hydroxyl radicals (OH) generated from H 2 O 2 trigger a self-propagating lipid peroxidation chain reaction

Code availability Python scripts for automated image analysis are available on References Meister, A

Endocrine Metab Immune Disord - Drug Targets (2019) 19:37381