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Description

The effect on the enzyme activity appeared to be dose dependent (Figure 11A, B)

Nuclear factor-B (NF-B), activation protein-1 (AP-1), nuclear factor erythroid 2 related factor 2 (Nrf2), and CREB-binding proteins (CBPs) are regulated and influenced by redox status and have been implicated in the transcriptional regulation of a wide range of genes that are involved in oxidative stress and cellular response mechanisms 23

By employing molecular docking and MD simulations, we aim to: (1) Characterize the binding modes of arbutin, glutathione, and sea cucumber peptides to hTYR