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CHAC1 further exacerbates cellular stress by degrading GSH, intensifying oxidative damage and ultimately driving ferroptotic cell death (Figure 5) ( FIGURE 5 While the eIF2K3/PERK-eIF2-ATF4 cascade, another branch of the ISR, can modulate ferroptosis in the context of ER stress, cysteine deprivation selectively activates GCN2 rather than PERK, highlighting distinct regulatory mechanisms ( Cysteine starvation triggers mitochondrial fragmentation, impairs mitochondrial function and leads to the accumulation of ROS ( CHAC1 is upregulated through the ATF4-dependent ISR pathway, where it degrades GSH to liberate cysteine needed for the synthesis of Fe-S cluster proteins (Ward et al., 2024)

Selenite modulates the level of phenolics and nutrient element to alleviate the toxicity of arsenite in rice ( Oryza sativa L.)

The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock

Vitamin B12 supplements (either oral or injectable) are normally taken to support a healthy nervous system and are often needed in people who are deficient in vitamin B12