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Here, we integrate Mendelian randomization (MR) and genetic colocalization approaches to characterize the gene-to-microbiome regulation in three intestinal tissues and to understand the mechanistic roles of the crosstalk between intestinal gene expression and microbiome in human complex diseases

Additionally, the interaction between alpha-synuclein and phospholipids in cell membranes can generate ROS, further exacerbating oxidative damage and neuronal dysfunction [163]