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10.1016/j.jconrel.2017.11.036 2 AlvenS.AderibigbeB

Many studies have revealed that iron overload might induce abnormal mitochondrial oxidative phosphorylation and abundant ROS production, thereby oxidizing polyunsaturated fatty acids (PUFAs) on cell and organelle membranes to form lipid peroxides, which further directly or indirectly destroy cell integrity and eventually trigger ferroptosis