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Keywords: Peyronies disease, Duplex Doppler ultrasound, Tunical plication, Plaque incision and grafting, Intralesional therapy, Oral Peyronies disease therapy, Dupuytrens disease, Ledderhose disease, Genetics INTRODUCTION Peyronies Disease (PD) is a superficial fibrosing condition of the penis characterized by the presence of fibrotic plaques often leading to penile deformity, with or without concomitant pain

Predrag Sikiric, Sven Seiwerth, Zeljko Grabarevic, Petek, M., Rucman, R., Turkovic, B., Ivo Rotkvic, Vjekoslav Jagic, Duvnjak, M., Mise, S., Sanja Djacic, Jadranka Separovic, Marija Veljaca, Ahmet Sallmani, Banic, M., & Brkic, T

These cells, while impervious to apoptosis-inducing therapies, remain vulnerable to lipid peroxidation, making ferroptosis a critical backdoor mechanism for eliminating residual, relapse-initiating cells (Lei et al., 2022)

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In one embodiment, the method further comprises separating the peptide conjugate from the reaction medium and optionally purifying the peptide conjugate