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92 Extracellular transport can occur through various mechanisms, all sharing a common principle: the movement of drugs within the fluid-filled spaces surrounding neurons via bulk fluid flow

This is the application area with the deepest preclinical history, and it is also where oral administration has a particularly direct anatomical rationale - the compound passes through the GI tract it was originally studied in relation to

References Al-Owain M, Kaya N, Al-Shamrani H, Al-Bakheet A, Qari A, Al-Muaigl S, Ghaziuddin M (2013) Autism spectrum disorder in a child with propionic acidemia

They have characteristics that are distinct from those of fibrosarcomas in other areas and behave more aggressively