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Spriestersbach, A., Kubicek, J., Schfer, F., Block, H

In the field of genetics, genome-wide association studies (GWAS) have highlighted a strong link between the LPA gene and PAD, indicating that therapeutic modulation of circulating Lp(a) could be effective for the PAD phenotype [137]

These effects were mediated through the modulation of key molecular markers, including Bax, caspase-3, Beclin 1, LC3 I/II, mitochondrial membrane potential, Bcl-2, p-p65, p-IKK/, and p-IB [114]

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Scientific study has also addressed its stability properties across biological matrices, pharmacokinetic behavior in preclinical species, and interaction with the dopaminergic system in controlled neurological research models