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Seefeldt T, Dwivedi C, Peitz G, Herman J, Carlson L, Zhang Z, et al

Nature 573 , 230234 (2019)

Consequently, pCB formulations emphasize a low oral bioavailability that led to the necessity of other administration routes to improve pCBs bioavailability and efficacy, such as the local (topical), transcutaneous (transdermal), pulmonary, and transmucosal routes [25] that include intranasal and rectal routes, with the last one demonstrating double the rate of bioavailability compared to the oral route [22]