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Erythema that persists beyond 72 hours without improvement suggests delayed hypersensitivity or low-grade infection, both of which require clinical assessment before the next scheduled dose

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We also outline current studies that support the involvement of the gut microbiota and mesenchymal cells in the development and progression of UC, with implications for therapeutic development

Hofstetter W, Correa AM, Bekele N, Ajani JA, Phan A, Komaki RR, Liao Z, Maru D, Wu TT, Mehran RJ, Rice DC , Roth JA, Vaporciyan AA, Walsh GL, Francis A, Blackmon S, Swisher SG

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