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An intramuscular injection delivers medication into a muscle

In the Philippines, where glutathione has been widely used for skin lightening, the Food and Drug Association of the Philippines FDA has issued a warning about serious side effects from injectable glutathione, including toxic effects on kidneys, liver, and the central nervous system, as well as a life-threatening skin rash

In subsequent experiments, we have elected to mutate both T291 and T292 together to overcome this potential issue

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Moreover, the use of a synthetic derivative of salinomycin (AM5) in breast CSCs induced iron depletion both in vitro and in vivo, mechanistically via the degradation of ferritin within lysosomes, leading to increased ROS production and subsequent selective breast CSCs death via ferroptosis [101]