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Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate-cysteine ligase

As the most powerful antioxidant with anti-aging properties, glutathione is essential for cleansing and detoxifying the body, particularly the liver

*Correspondence: Lili Zhou, [email protected] These authors have contributed equally to this work This article was submitted to Renal Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Preclinical models have demonstrated that PKC inhibition by leucovorin completely reversed the elevated frequency and amplitude of miniature EPSCs in BIPN model rats