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Key Takeaway: Glutathione is a triple-threat amino acid compound that acts as the body's primary internal shield against cellular damage and toxic buildup

Furthermore, a different approach using intragastrically administered rotenone (5 mg/Kg) in mice showed that the accumulation and aggregation of -synuclein in neurons of the dorsal motor nucleus of the vagus (DMV) and the intermediolateral nucleus (IML) in the spinal cord was accompanied by the selective loss of dopaminergic neurons and astrogliosis, suggesting that the gastric administration of rotenone through the connection of the enteric nervous system (ENS) with anatomical structures of the CNS also induces PD-like features [11,19]

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SCENIC+ infers transcription factor activity and identifies potential corresponding candidate enhancer regions and regulated genes network (eRegulons) 24 , and we applied it on our sn multiomic data