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[DOI] [PubMed] [Google Scholar] 207.Kobzik L, Reid MB, Bredt DS, Stamler JS

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KEGG pathway enrichment analysis indicated that this cluster was highly enriched for the vesicle cycle pathway, which is closely associated with protein secretion, as well as several other secretion-related pathways (Fig

Specifically, under PF conditions, increased ER stress in AEC2 resulted in impaired lipid synthesis, in particular a reduction in unsaturated fatty acid synthesis mediated by stearoyl coenzyme A desaturase 1 (SCD1) Reduced SCD1 activity not only impeded resolution of endoplasmic reticulum stress, but also exacerbated cellular dysfunction, thereby triggering a fibrotic response (Romero et al., 2018a)