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Furthermore, the triple substitutions considerably potentiate complement-mediated killing or phagocytosis of not only cancer cells but also gram-positive and gram-negative bacteria

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This results in -helix 15 being displaced by 8 and -helix 16 by as much as 11 from their original position (Fig

GS catalyzes the addition of glycine to -glutamylcysteine created by GCLC to form GSH [1]