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Attenuated expression of the tight junction proteins is involved in Clopidogrel-induced gastric injury through p38 MAPK activation

Specifically, we show that AR directly represses BCL-2 transcription via binding to multiple ARBS across the BCL-2 genomic region, especially the ARBS1 around the promoter, and castration and ARPI treatment block AR engagement to most ARBS leading to de-repression of BCL-2 transcription