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doi: 10.1016/j.biopha.2017.10.084 57 TzengTFLiouSSChangCJLiuIM

Global patterns in the epidemiology, cancer risk, and surgical implications of inflammatory bowel disease

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The PM-induced imbalance in the intestinal flora leads to a decrease in the production of beneficial metabolites, such as SCFAs (91), and an increase in harmful metabolites, such as LPS ( 3 increase in PM 2.5 concentration, the -diversity of the intestinal flora decreases by 2.16%, the relative abundance of Bacteroidetes declines, and the fecal levels of beneficial SCFAsincluding isobutyric acid and isovaleric acid levelsdecrease with worsening disease (85, 92)

For biweekly (every 2 weeks) dosing: Talvey is given in three step-up doses on day 1, day 4, and day 7, followed by the first full treatment on day 10