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Hypertensive patients have been observed to produce high levels of hydrogen peroxide, superoxide anion, and NO in leukocytes [290,291,292], exhibit elevated lipid peroxidation in erythrocytes, and display elevated concentrations of 8-isoprostanes in plasma [293]

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De Andrade KQ, et al

For example, a 19-year-old woman had been diagnosed with glutathione synthetase deficiency shortly after birth and then, despite an initial severe presentation, had normal intellectual development and few disease-related complications with a treatment regimen that included Polycitra (citric acid, potassium citrate, and sodium citrate), vitamin C, vitamin E, and selenium (08)

Conversely, cytokines such as IL-4, IL-13, and macrophage colony-stimulating factor (M-CSF) drive polarization toward the M2 phenotype, which secretes anti-inflammatory factors including IL-4, IL-10, and IL-13 (35)