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To understand the relationship between circulating PAGln levels, physiological indicators of cardiac and vascular function, and microbial species found in the gut microbiome, we plotted four-way associations of the mean circulating PAGln levels (color schematic), plasma nitrite levels (symbol size), relative abundance of Staphylococcus or Lactobacillus and either LVEDP or ex vivo maximal relaxation (Fig

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Most nausea occurs during the first few days after dose escalation and diminishes significantly by weeks two and three at the new level

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