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Nusinersen versus Sham control in infantile-onset spinal muscular atrophy

In the ALDEFLUOR assay (01700, STEMCELL Technologies, Vancouver, CA), functional stem cells were analyzed and isolated based on the fact that aldehyde dehydrogenase (ALDH) is a widely recognized key marker for breast CSCs 68

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Because B-cell targeting by monoclonal antibodies is not approved as treatment for SLE, idiopathic inflammatory myositis, and systemic sclerosis, previous exposure to such agents was not a prerequisite for treatment, they added