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Like nausea, diarrhea tends to be dose-dependent and occurs most frequently during treatment initiation and dose increases

A limitation inherent to all in vitro experiments is that our results may not reflect in vivo biologic behavior in dogs experiencing clinical ITZ-associated hepatotoxicity

EGCG, a compound with neuroprotective effects, has been found to modulate microglial activation, reduce neuroinflammation, suppress pro-inflammatory cytokines, and decrease oxidative stress

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2.2 Mood-stabilizers 2.2.1 Lithium The role of PKC in the pathophysiology of bipolar disorder was suggested in 1994 by Manji and colleagues after observing that chronic lithium use has PKC-dependent transcriptional and posttranscriptional effects involving long-term neuroplasticity and cellular response